2KM3

Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats

Summary for 2KM3

Related143D 1K8P 2AQY 2GKU 2JSK 2JSL 2JSM 2JSQ 2KF7 2KF8
DescriptorDNA (5'-D(*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*G)-3') (1 entity in total)
Functional Keywordsanticancer targets, ctaggg repeat, g-quadruplex, human telomere instability, dna
Total number of polymer chains1
Total molecular weight6938.46
Authors
Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T. (deposition date: 2009-07-17, release date: 2009-11-03, Last modification date: 2011-07-13)
Primary citation
Lim, K.W.,Alberti, P.,Guedin, A.,Lacroix, L.,Riou, J.F.,Royle, N.J.,Mergny, J.L.,Phan, A.T.
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad
Nucleic Acids Res., 37:6239-6248, 2009
PubMed: 19692585 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkp630
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

Clashscore13MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

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Molmil generated image of 2km3
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Molmil generated image of 2km3
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