2JJC

Hsp90 alpha ATPase domain with bound small molecule fragment

Summary for 2JJC

Entry DOI	10.2210/pdb2jjc/pdb
Related	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2UWD 2VCI 2VCJ
Descriptor	HEAT SHOCK PROTEIN HSP 90-ALPHA, DIMETHYL SULFOXIDE, PYRIMIDIN-2-AMINE, ... (4 entities in total)
Functional Keywords	hsp90, atpase, chaperone, cytoplasm, heat shock, nucleotide-binding, alternative splicing, atp-binding, phosphoprotein, stress response
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P07900
Total number of polymer chains	1
Total formula weight	24579.80
Authors	Congreve, M.,Chessari, G.,Tisi, D.,Woodhead, A.J. (deposition date: 2008-03-31, release date: 2008-07-15, Last modification date: 2023-12-13)
Primary citation	Congreve, M.,Chessari, G.,Tisi, D.,Woodhead, A.J. Recent Developments in Fragment-Based Drug Discovery. J.Med.Chem., 51:3661-, 2008 Cited by PubMed: 18457385 DOI: 10.1021/JM8000373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation