2JBP
Protein kinase MK2 in complex with an inhibitor (crystal form-2, co- crystallization)
Summary for 2JBP
Entry DOI | 10.2210/pdb2jbp/pdb |
Related | 1KWP 1NXK 1NY3 2JBO |
Descriptor | MAP KINASE-ACTIVATED PROTEIN KINASE 2, 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (3 entities in total) |
Functional Keywords | ser-thr kinase, mapkap kinase 2, phosphorylation, small molecule inhibitor, mk2, kinase, atp site, transferase, atp- binding, serine/threonine-protein kinase, co-crystallization, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 12 |
Total formula weight | 455729.69 |
Authors | Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U. (deposition date: 2006-12-09, release date: 2007-03-20, Last modification date: 2023-12-13) |
Primary citation | Hillig, R.C.,Eberspaecher, U.,Monteclaro, F.,Huber, M.,Nguyen, D.,Mengel, A.,Muller-Tiemann, B.,Egner, U. Structural basis for a high affinity inhibitor bound to protein kinase MK2. J. Mol. Biol., 369:735-745, 2007 Cited by PubMed: 17449059DOI: 10.1016/j.jmb.2007.03.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.31 Å) |
Structure validation
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