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2JB4

Isopenicillin N synthase with a 2-thiabicycloheptan-6-one product analogue

Summary for 2JB4
Entry DOI10.2210/pdb2jb4/pdb
Related1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ
DescriptorIsopenicillin N synthase, (1S,4S,5S,7R)-7-{[(5S)-5-AMINO-5-CARBOXYPENTANOYL]AMINO}-3,3-DIMETHYL-6-OXO-2-THIABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID, FE (III) ION, ... (6 entities in total)
Functional Keywordsantibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, oxidoreductase, b-lactam antibiotic
Biological sourceEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Total number of polymer chains1
Total formula weight38262.31
Authors
Stewart, A.C.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2006-12-01, release date: 2007-10-16, Last modification date: 2024-05-08)
Primary citationStewart, A.C.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J.
A Cyclobutanone Analogue Mimics Penicillin in Binding to Isopenicillin N Synthase.
Chembiochem, 8:2003-, 2007
Cited by
PubMed: 17907118
DOI: 10.1002/CBIC.200700176
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

222036

數據於2024-07-03公開中

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