2J2S

Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

Summary for 2J2S

• Entry DOI: 10.2210/pdb2j2s/pdb
• Related: 2AGH
• Descriptor: ZINC FINGER PROTEIN HRX, ZINC ION (2 entities in total)
• Functional Keywords: transcription regulation, chromosomal rearrangement, zinc-finger, dna-binding, bromodomain, polymorphism, mixed lineage leukaemia, zinc binding, transcription, metal-binding, zinc, cxxc, mbd1, hox genes, chromatin, methylation, proto-oncogene, nuclear protein, phosphorylation, cpg dinucleotide, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 1
• Total formula weight: 8197.48

Authors

Allen, M.D.,Grummitt, C.G.,Hilcenko, C.,Young-Min, S.,Tonkin, L.M.,Johnson, C.M.,Bycroft, M.,Warren, A.J. (deposition date: 2006-08-17, release date: 2006-08-21, Last modification date: 2017-04-19)

• Primary citation: Allen, M.D.,Grummitt, C.G.,Hilcenko, C.,Min, S.Y.,Tonkin, L.M.,Johnson, C.M.,Freund, S.M.,Bycroft, M.,Warren, A.J.; Solution Structure of the Nonmethyl-Cpg-Binding Cxxc Domain of the Leukaemia-Associated Mll Histone Methyltransferase; Embo J., 25:4503-, 2006; PubMed: 16990798; DOI: 10.1038/SJ.EMBOJ.7601340

Experimental method

SOLUTION NMR