2IUH
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide
Summary for 2IUH
Entry DOI | 10.2210/pdb2iuh/pdb |
Related | 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUI |
Descriptor | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT, C-KIT PHOSPHOTYROSYL PEPTIDE (3 entities in total) |
Functional Keywords | transferase, polymorphism, ubl conjugation, phosphorylation, p85, sh2, pi3k, sh2 domain, sh3 domain, pi3-kinase, disease mutation |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 15305.01 |
Authors | Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. (deposition date: 2006-06-03, release date: 2006-06-06, Last modification date: 2021-04-28) |
Primary citation | Nolte, R.T.,Eck, M.J.,Schlessinger, J.,Shoelson, S.E.,Harrison, S.C. Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3:364-, 1996 Cited by PubMed: 8599763DOI: 10.1038/NSB0496-364 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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