2I5X
Engineering the PTPbeta catalytic domain with improved crystallization properties
Summary for 2I5X
Entry DOI | 10.2210/pdb2i5x/pdb |
Related | 2I4G 2I4H |
Descriptor | Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, (4-ETHYLPHENYL)SULFAMIC ACID, ... (5 entities in total) |
Functional Keywords | protein tyrosine phosphatase, wpd-loop, drug design, protein engineering, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein (Potential): P23467 |
Total number of polymer chains | 2 |
Total formula weight | 73073.77 |
Authors | Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M.,Klopfenstein, S. (deposition date: 2006-08-26, release date: 2006-09-05, Last modification date: 2023-08-30) |
Primary citation | Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr.,Sect.D, 62:1435-1445, 2006 Cited by PubMed: 17139078DOI: 10.1107/S0907444906037784 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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