2I4Q

Human renin/PF02342674 complex

Summary for 2I4Q

Entry DOI	10.2210/pdb2i4q/pdb
Related	2G1S 2G21 2G24
Descriptor	Renin, (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE (3 entities in total)
Functional Keywords	renin inhibitor, protein-ligand complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	74732.09
Authors	Holsworth, D.D.,Jalaie, M.,Zhang, E.,Mcconnell, P.,Mochalkin, I.,Finzel, B.C. (deposition date: 2006-08-22, release date: 2006-10-24, Last modification date: 2011-07-13)
Primary citation	Powell, N.A.,Ciske, F.L.,Cai, C.,Holsworth, D.D.,Mennen, K.,Van Huis, C.A.,Jalaie, M.,Day, J.,Mastronardi, M.,McConnell, P.,Mochalkin, I.,Zhang, E.,Ryan, M.J.,Bryant, J.,Collard, W.,Ferreira, S.,Gu, C.,Collins, R.,Edmunds, J.J. Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorg.Med.Chem., 15:5912-5949, 2007 Cited by PubMed: 17574423 DOI: 10.1016/j.bmc.2007.05.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation