2I16

Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K

Summary for 2I16

Entry DOI	10.2210/pdb2i16/pdb
Related	1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1US0 2ACQ 2ACR 2I17
Descriptor	Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (5 entities in total)
Functional Keywords	oxidoreductase, nadp, idd594
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37444.25
Authors	Petrova, T.,Ginell, S.,Mitshler, A.,Hasemann, I.,Schneider, T.,Cousido, A.,Lunin, V.Y.,Joachimiak, A.,Podjarny, A. (deposition date: 2006-08-13, release date: 2006-08-29, Last modification date: 2023-08-30)
Primary citation	Petrova, T.,Ginell, S.,Mitschler, A.,Hazemann, I.,Schneider, T.,Cousido, A.,Lunin, V.Y.,Joachimiak, A.,Podjarny, A. Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat. Acta Crystallogr.,Sect.D, 62:1535-1544, 2006 Cited by PubMed: 17139089 DOI: 10.1107/S0907444906041035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.81 Å)

Structure validation