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1EF3

FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE

Summary for 1EF3
Entry DOI10.2210/pdb1ef3/pdb
DescriptorALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (4 entities in total)
Functional Keywordsbeta barrel, protein-inhibitor complex, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P15121
Total number of polymer chains2
Total formula weight73579.55
Authors
Oka, M.,Matsumoto, Y.,Sugiyama, S.,Tsuruta, N.,Matsushima, M. (deposition date: 2000-02-06, release date: 2001-02-07, Last modification date: 2023-08-09)
Primary citationOka, M.,Matsumoto, Y.,Sugiyama, S.,Tsuruta, N.,Matsushima, M.
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
J.Med.Chem., 43:2479-2483, 2000
Cited by
PubMed: 10882376
DOI: 10.1021/jm990502r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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