1EL3

HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR

Summary for 1EL3

• Entry DOI: 10.2210/pdb1el3/pdb
• Descriptor: ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE, ... (4 entities in total)
• Functional Keywords: aldose reductase, inhibition, diabetes, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37032.20

Authors

Podjarny, A. (deposition date: 2000-03-13, release date: 2000-05-10, Last modification date: 2024-04-03)

• Primary citation: Calderone, V.,Chevrier, B.,Van Zandt, M.,Lamour, V.,Howard, E.,Poterszman, A.,Barth, P.,Mitschler, A.,Lu, J.,Dvornik, D.M.,Klebe, G.,Kraemer, O.,Moorman, A.R.,Moras, D.,Podjarny, A.; The structure of human aldose reductase bound to the inhibitor IDD384.; Acta Crystallogr.,Sect.D, 56:536-540, 2000; PubMed: 10771421; DOI: 10.1107/S0907444900002341

Experimental method

X-RAY DIFFRACTION (1.7 Å)