2GTW

Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution

2GTW の概要

• エントリーDOI: 10.2210/pdb2gtw/pdb
• 関連するPDBエントリー: 1JF1 1JHT 2GT9 2GTZ 2GUO
• 分子名称: HLA-A*0201 heavy chain, Beta-2-microglobulin, octapeptide from Melan-A/MART-1, ... (7 entities in total)
• 機能のキーワード: melan-a/mart-1 peptide, nonapeptide, mhc class i, hla-a2, a27l mutation, melanoma, cancer vaccines, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P61769; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89869.79

構造登録者

Borbulevych, O.Y.,Baker, B.M. (登録日: 2006-04-28, 公開日: 2007-06-12, 最終更新日: 2023-08-30)

• 主引用文献: Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M.; Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition; J.Mol.Biol., 372:1123-1136, 2007; PubMed: 17719062; DOI: 10.1016/j.jmb.2007.07.025

実験手法

X-RAY DIFFRACTION (1.548 Å)