2FX8
Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41
Summary for 2FX8
Entry DOI | 10.2210/pdb2fx8/pdb |
Related | 1TZG 2FX7 2FX9 |
Descriptor | Fab 4E10, Fragment of HIV glycoprotein (GP41), ... (4 entities in total) |
Functional Keywords | immunoglobulin fold, beta-sandwich, antibody-epitope complex, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P05880 |
Total number of polymer chains | 12 |
Total formula weight | 195045.47 |
Authors | Cardoso, R.M.F.,Brunel, F.M.,Ferguson, S.,Burton, D.R.,Dawson, P.E.,Wilson, I.A. (deposition date: 2006-02-03, release date: 2006-12-19, Last modification date: 2023-11-15) |
Primary citation | Cardoso, R.M.,Brunel, F.M.,Ferguson, S.,Zwick, M.,Burton, D.R.,Dawson, P.E.,Wilson, I.A. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. J.Mol.Biol., 365:1533-1544, 2007 Cited by PubMed: 17125793DOI: 10.1016/j.jmb.2006.10.088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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