2FX8
Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (L, M, N, O) | Fab 4E10 | polymer | 214 | 23292.7 | 4 | Homo sapiens (human) | ||
| 2 | B, D, F, H (H, I, J, K) | Fab 4E10 | polymer | 227 | 23860.8 | 4 | Homo sapiens (human) | ||
| 3 | I, J, K, L (P, Q, R, S) | Fragment of HIV glycoprotein (GP41) | polymer | 12 | 1607.8 | 4 | UniProt (P05880) | ||
| 4 | M, N, O, P, Q... (L, H, M, I, N...) | water | water | 18.0 | 600 | Chemie (HOH) |
Sequence modifications
P, Q, R, S: 671 - 682 (UniProt: P05880)
| PDB | External Database | Details |
|---|---|---|
| Arg 681 | Tyr 672 | engineered mutation |
| Arg 682 | Ile 673 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 195045.5 | |
| All* | Total formula weight | 195045.5 |
