2E9V

Structure of h-CHK1 complexed with A859017

Summary for 2E9V

• Entry DOI: 10.2210/pdb2e9v/pdb
• Related: 2AYP 2E9N 2E9O 2E9P 2E9U 2FGA 2GHG
• Descriptor: Serine/threonine-protein kinase Chk1, 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE (3 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 62838.96

Authors

Park, C. (deposition date: 2007-01-27, release date: 2008-01-29, Last modification date: 2024-03-13)

• Primary citation: Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gwaltney, S.L.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H.; Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)