2E9U
Structure of h-CHK1 complexed with A780125
Summary for 2E9U
Entry DOI | 10.2210/pdb2e9u/pdb |
Related | 2AYP 2E9N 2E9O 2E9P 2E9V 2FGA 2GHG |
Descriptor | Serine/threonine-protein kinase Chk1, 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31417.53 |
Authors | Park, C. (deposition date: 2007-01-27, release date: 2008-01-29, Last modification date: 2024-03-13) |
Primary citation | Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gwaltney, S.L.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H. Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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