2E9N
Structure of h-CHK1 complexed with A767085
Summary for 2E9N
Entry DOI | 10.2210/pdb2e9n/pdb |
Related | 2AYP 2E9O 2E9P 2E9U 2E9V 2FGA 2GHG |
Descriptor | Serine/threonine-protein kinase Chk1, 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE (3 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31534.28 |
Authors | Park, C. (deposition date: 2007-01-26, release date: 2008-01-29, Last modification date: 2024-03-13) |
Primary citation | Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gu, W.Z.,Gwaltney, S.L.,Judge, R.A.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H. Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg.Med.Chem., 15:2759-2767, 2007 Cited by PubMed: 17287122DOI: 10.1016/j.bmc.2007.01.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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