2E9N

Structure of h-CHK1 complexed with A767085

Summary for 2E9N

Related2AYP 2FGA 2GHG 2E9O 2E9P 2E9U 2E9V
DescriptorSerine/threonine-protein kinase Chk1, 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE (3 entities in total)
Functional Keywordsprotein-inhibitor complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus O14757
Total number of polymer chains1
Total molecular weight31534.29
Authors
Park, C. (deposition date: 2007-01-26, release date: 2008-01-29, Last modification date: 2011-07-13)
Primary citation
Tong, Y.,Claiborne, A.,Stewart, K.D.,Park, C.,Kovar, P.,Chen, Z.,Credo, R.B.,Gu, W.Z.,Gwaltney, S.L.,Judge, R.A.,Zhang, H.,Rosenberg, S.H.,Sham, H.L.,Sowin, T.J.,Lin, N.H.
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15:2759-2767, 2007
PubMed: 17287122 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmc.2007.01.012
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers324.5%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution