2CLT

Crystal structure of the active form (full-length) of human fibroblast collagenase.

Summary for 2CLT

Entry DOI	10.2210/pdb2clt/pdb
Related	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2TCL 3AYK 4AYK 966C
Descriptor	INTERSTITIAL COLLAGENASE, CALCIUM ION, ZINC ION, ... (4 entities in total)
Functional Keywords	extracellular matrix, fibroblast collagenase, zinc, calcium, zymogen, protease, collagen, autocatalytic cleavage, matrix metalloproteinases, hydrolase, polymorphism, glycoprotein, metal-binding, inhibitor-free, metalloprotease, collagen degradation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P03956
Total number of polymer chains	2
Total formula weight	85042.40
Authors	Iyer, S.,Visse, R.,Nagase, H.,Acharya, K.R. (deposition date: 2006-04-29, release date: 2006-08-09, Last modification date: 2023-12-13)
Primary citation	Iyer, S.,Visse, R.,Nagase, H.,Acharya, K.R. Crystal Structure of an Active Form of Human Mmp-1. J.Mol.Biol., 362:78-, 2006 Cited by PubMed: 16890240 DOI: 10.1016/J.JMB.2006.06.079 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation