2C0I

Src family kinase Hck with bound inhibitor A-420983

2C0I の概要

• エントリーDOI: 10.2210/pdb2c0i/pdb
• 関連するPDBエントリー: 1AD5 1BU1 1QCF 2C0O 2C0T 2HCK 3HCK 4HCK 5HCK
• 分子名称: TYROSINE-PROTEIN KINASE HCK, N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: tyrosine-protein kinase, transferase, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, palmitate, phosphorylation, sh2 domain, sh3 domain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105268.05

構造登録者

Borhani, D.W.,Burchat, A.,Calderwood, D.J.,Hirst, G.C.,Li, B.,Loew, A. (登録日: 2005-09-03, 公開日: 2006-09-20, 最終更新日: 2023-12-13)

• 主引用文献: Burchat, A.,Borhani, D.W.,Calderwood, D.J.,Hirst, G.C.,Li, B.,Stachlewitz, R.F.; Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.; Bioorg.Med.Chem.Lett., 16:118-, 2006; PubMed: 16216497; DOI: 10.1016/J.BMCL.2005.09.039

実験手法

X-RAY DIFFRACTION (2.3 Å)