2BMC

Aurora-2 T287D T288D complexed with PHA-680632

2BMC の概要

関連するPDBエントリー1MQ4 1MUO 1OL5 1OL6 1OL7
分子名称SERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE (3 entities in total)
機能のキーワードcell cycle, transferase, serine/threonine-protein kinase, atp-binding, phosphorylation
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数6
分子量合計214816.53
構造登録者
主引用文献
Fancelli, D.,Berta, D.,Bindi, S.,Cameron, A.,Cappella, P.,Carpinelli, P.,Catana, C.,Forte, B.,Giordano, P.,Giorgini, M.L.,Mantegani, S.,Marsiglio, A.,Meroni, M.,Moll, J.,Pittala, V.,Roletto, F.,Severino, D.,Soncini, C.,Storici, P.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P.
Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition.
J.Med.Chem., 48:3080-, 2005
PubMed: 15828847 (主引用文献が同じPDBエントリー)
DOI: 10.1021/JM049076M
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.6 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers14 0.7% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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