2AST
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
Summary for 2AST
Entry DOI | 10.2210/pdb2ast/pdb |
Related | 1FQV 2ASS |
Descriptor | S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ... (6 entities in total) |
Functional Keywords | scf-substrate complex, lrr, cell cycle, protein turnover complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P46527 |
Total number of polymer chains | 4 |
Total formula weight | 65908.13 |
Authors | Hao, B.,Zhang, N.,Schulman, B.A.,Wu, G.,Pagano, M.,Pavletich, N.P. (deposition date: 2005-08-24, release date: 2005-10-18, Last modification date: 2023-08-23) |
Primary citation | Hao, B.,Zheng, N.,Schulman, B.A.,Wu, G.,Miller, J.J.,Pagano, M.,Pavletich, N.P. Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase. Mol.Cell, 20:9-19, 2005 Cited by PubMed: 16209941DOI: 10.1016/j.molcel.2005.09.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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