2A6H

Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin

Summary for 2A6H

Entry DOI	10.2210/pdb2a6h/pdb
Related	1IW7 1SMY 2A68 2A69 2A6E
Descriptor	DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
Functional Keywords	rna polymerase holoenzyme, streptolydigin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
Biological source	Thermus thermophilus More
Cellular location	Cytoplasm : Q5SKW1
Total number of polymer chains	12
Total formula weight	854782.62
Authors	Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-07-02, release date: 2005-09-20, Last modification date: 2023-08-23)
Primary citation	Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Kashkina, E.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G. Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19:655-666, 2005 Cited by PubMed: 16167380 DOI: 10.1016/j.molcel.2005.07.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation