2WUB
Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp
Summary for 2WUB
Entry DOI | 10.2210/pdb2wub/pdb |
Related | 1YBW 1YC0 2WUC |
Descriptor | HEPATOCYTE GROWTH FACTOR ACTIVATOR LONG CHAIN, HEPATOCYTE GROWTH FACTOR ACTIVATOR SHORT CHAIN, FAB FRAGMENT FAB40.DELTATRP HEAVY CHAIN, ... (6 entities in total) |
Functional Keywords | hydrolase immune system complex, disulfide bond, serine protease, egf-like domain, allosteric inhibitor, kringle, zymogen, protease, secreted, antibody, hydrolase, fab complex, polymorphism, glycoprotein, hydrolase-immune system complex, hydrolase/immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 8 |
Total formula weight | 158709.95 |
Authors | Ganesan, R.,Eigenbrot, C.,Shia, S. (deposition date: 2009-10-01, release date: 2009-12-15, Last modification date: 2023-12-20) |
Primary citation | Ganesan, R.,Eigenbrot, C.,Wu, Y.,Liang, W.C.,Shia, S.,Lipari, M.T.,Kirchhofer, D. Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody Structure, 17:1614-, 2009 Cited by PubMed: 20004165DOI: 10.1016/J.STR.2009.09.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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