2HZI

Abl kinase domain in complex with PD180970

Summary for 2HZI

Entry DOI	10.2210/pdb2hzi/pdb
Related	2HYY 2HZ0 2HZ4
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE (3 entities in total)
Functional Keywords	tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	2
Total formula weight	64959.92
Authors	Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-09, release date: 2007-01-16, Last modification date: 2024-02-21)
Primary citation	Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007 Cited by PubMed: 17164530 DOI: 10.1107/S0907444906047287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation