2HZI
Abl kinase domain in complex with PD180970
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 277 | 32050.7 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (human) | p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | A, B | 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 429.3 | 2 | Chemie (JIN) | |||
| 3 | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 500 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 224 | - | cloning artifact |
| Ala 225 | - | cloning artifact |
| Met 226 | - | cloning artifact |
| Asp 227 | - | cloning artifact |
| Pro 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64101.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 858.5 | |
| All* | Total formula weight | 64959.9 |
