2HZ4

Abl kinase domain unligated and in complex with tetrahydrostaurosporine

Summary for 2HZ4

• Entry DOI: 10.2210/pdb2hz4/pdb
• Related: 2HYY 2HZ0
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE (3 entities in total)
• Functional Keywords: tyrosine kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• Total number of polymer chains: 3
• Total formula weight: 96446.54

Authors

Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-08, release date: 2007-01-16, Last modification date: 2024-02-21)

• Primary citation: Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W.; Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.; ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007; PubMed: 17164530; DOI: 10.1107/S0907444906047287

Experimental method

X-RAY DIFFRACTION (2.8 Å)