2HZ0

Abl kinase domain in complex with NVP-AEG082

Summary for 2HZ0

• Entry DOI: 10.2210/pdb2hz0/pdb
• Related: 2HYY
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE (3 entities in total)
• Functional Keywords: tyrosine kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• Total number of polymer chains: 2
• Total formula weight: 63526.80

Authors

Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-08, release date: 2007-01-16, Last modification date: 2023-08-30)

• Primary citation: Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W.; Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.; ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007; PubMed: 17164530; DOI: 10.1107/S0907444906047287

Experimental method

X-RAY DIFFRACTION (2.1 Å)