2HYY

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Summary for 2HYY

Entry DOI	10.2210/pdb2hyy/pdb
Related	1FPU 1IEP
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
Functional Keywords	tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	4
Total formula weight	128687.54
Authors	Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-08, release date: 2007-01-16, Last modification date: 2023-08-30)
Primary citation	Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007 Cited by PubMed: 17164530 DOI: 10.1107/S0907444906047287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation