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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HYY

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE STI A 600

Chain	Residue
A	LEU248
A	PHE317
A	MET318
A	ILE360
A	HIS361
A	ALA380
A	ASP381
A	PHE382
A	TYR253
A	VAL256
A	ALA269
A	LYS271
A	GLU286
A	MET290
A	VAL299
A	THR315

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE STI B 600

Chain	Residue
B	HOH112
B	VAL256
B	ALA269
B	LYS271
B	GLU286
B	MET290
B	VAL299
B	ILE313
B	THR315
B	PHE317
B	MET318
B	ILE360
B	HIS361
B	ALA380
B	ASP381
B	PHE382

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE STI C 600

Chain	Residue
C	HOH38
C	HOH126
C	TYR253
C	ALA269
C	LYS271
C	GLU286
C	MET290
C	ILE293
C	VAL299
C	ILE313
C	THR315
C	MET318
C	ILE360
C	HIS361
C	LEU370
C	ALA380
C	ASP381
C	PHE382

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE STI D 600

Chain	Residue
D	HOH151
D	TYR253
D	ALA269
D	LYS271
D	GLU286
D	MET290
D	ILE293
D	VAL299
D	ILE313
D	THR315
D	PHE317
D	MET318
D	ILE360
D	HIS361
D	ALA380
D	ASP381
D	PHE382

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK

Chain	Residue	Details
A	LEU248-LYS271

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV

Chain	Residue	Details
A	PHE359-VAL371

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP363
B	ASP363
C	ASP363
D	ASP363

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LEU248
D	LEU248
D	LYS271
D	GLU316
A	LYS271
A	GLU316
B	LEU248
B	LYS271
B	GLU316
C	LEU248
C	LYS271
C	GLU316

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P42684

Chain	Residue	Details
A	SER229
B	SER229
C	SER229
D	SER229

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	TYR253
D	TYR253
D	TYR257
D	TYR413
A	TYR257
A	TYR413
B	TYR253
B	TYR257
B	TYR413
C	TYR253
C	TYR257
C	TYR413

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269\|PubMed:16912036

Chain	Residue	Details
A	TYR393
B	TYR393
C	TYR393
D	TYR393

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P00520

Chain	Residue	Details
A	SER446
B	SER446
C	SER446
D	SER446

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP363
A	ARG367

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN368
B	ASP363
B	ALA365

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN368
C	ASP363
C	ALA365

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN368
D	ASP363
D	ALA365

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP363
B	ARG367

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP363
C	ARG367

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP363
D	ARG367

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP363
A	ALA365

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP363
B	ALA365

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP363
C	ALA365

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP363
D	ALA365

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN368
A	ASP363
A	ALA365

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