1IEP
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
Summary for 1IEP
Entry DOI | 10.2210/pdb1iep/pdb |
Related | 1FPU |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL, CHLORIDE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (4 entities in total) |
Functional Keywords | kinase, kinase inhibitor, sti-571, activation loop, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 68686.97 |
Authors | Nagar, B.,Bornmann, W.,Schindler, T.,Clarkson, B.,Kuriyan, J. (deposition date: 2001-04-10, release date: 2001-04-18, Last modification date: 2023-08-09) |
Primary citation | Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.R.,Miller, W.T.,Clarkson, B.,Kuriyan, J. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) Cancer Res., 62:4236-4243, 2002 Cited by PubMed: 12154025PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report