2GTW
Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution
Summary for 2GTW
Entry DOI | 10.2210/pdb2gtw/pdb |
Related | 1JF1 1JHT 2GT9 2GTZ 2GUO |
Descriptor | HLA-A*0201 heavy chain, Beta-2-microglobulin, octapeptide from Melan-A/MART-1, ... (7 entities in total) |
Functional Keywords | melan-a/mart-1 peptide, nonapeptide, mhc class i, hla-a2, a27l mutation, melanoma, cancer vaccines, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P61769 Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655 |
Total number of polymer chains | 6 |
Total formula weight | 89869.79 |
Authors | Borbulevych, O.Y.,Baker, B.M. (deposition date: 2006-04-28, release date: 2007-06-12, Last modification date: 2023-08-30) |
Primary citation | Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M. Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol., 372:1123-1136, 2007 Cited by PubMed: 17719062DOI: 10.1016/j.jmb.2007.07.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.548 Å) |
Structure validation
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