1TN8

Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A Resolution

Summary for 1TN8

Entry DOI	10.2210/pdb1tn8/pdb
Related	1D8D 1FPP 1FT1 1N4Q 1QBQ 1TN6 1TN7 1TNB 1TNO 1TNU 1TNY 1TNZ
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, peptide derived from the C-terminus of H-Ras, ... (7 entities in total)
Functional Keywords	ftase, farnesyltransferase, farnesyl transferase, prenyltransferase, caax, ras, lipid modification, prenylation, substrate selectivity, transferase
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	3
Total formula weight	93782.86
Authors	Reid, T.S.,Terry, K.L.,Casey, P.J.,Beese, L.S. (deposition date: 2004-06-11, release date: 2004-11-02, Last modification date: 2023-08-23)
Primary citation	Reid, T.S.,Terry, K.L.,Casey, P.J.,Beese, L.S. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J.Mol.Biol., 343:417-433, 2004 Cited by PubMed: 15451670 DOI: 10.1016/j.jmb.2004.08.056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation