1TN8
Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A Resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | polymer | 377 | 44098.1 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha |
| 2 | B (B) | Protein farnesyltransferase beta subunit | polymer | 437 | 48722.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Norway rat) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C (C) | peptide derived from the C-terminus of H-Ras | polymer | 5 | 477.6 | 1 | |||
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (B) | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | non-polymer | 359.4 | 1 | Chemie (FII) | |||
| 6 | F (B) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 7 | G, H, I (A, B, C) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 93298.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 484.9 | |
| All* | Total formula weight | 93782.9 |
