1TK8

T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site

Summary for 1TK8

• Entry DOI: 10.2210/pdb1tk8/pdb
• Related: 1T8E 1TK0 1TK5 1TKD
• Descriptor: 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DA))-3', 5'-D(*CP*CP*CP*AP*(8OG)P*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ... (10 entities in total)
• Functional Keywords: 8-oxoguanosine dna polymerase, transferase-electron transport-dna complex, transferase/electron transport/dna
• Biological source: Enterobacteria phage T7; More
• Total number of polymer chains: 4
• Total formula weight: 106677.69

Authors

Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T. (deposition date: 2004-06-08, release date: 2004-08-31, Last modification date: 2023-08-23)

• Primary citation: Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T.; Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.; Embo J., 23:3452-3461, 2004; PubMed: 15297882; DOI: 10.1038/sj.emboj.7600354

Experimental method

X-RAY DIFFRACTION (2.5 Å)