T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site

Summary for 1TK8

Related1T8E 1TK0 1TK5 1TKD
Descriptor5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DA))-3', 5'-D(*CP*CP*CP*AP*(8OG)P*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ... (10 entities in total)
Functional Keywords8-oxoguanosine dna polymerase, transferase-electron transport-dna complex, transferase/electron transport/dna
Biological sourceEnterobacteria phage T7
Total number of polymer chains4
Total molecular weight106677.69
Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T. (deposition date: 2004-06-08, release date: 2004-08-31, Last modification date: 2011-07-13)
Primary citation
Brieba, L.G.,Eichman, B.F.,Kokoska, R.J.,Doublie, S.,Kunkel, T.A.,Ellenberger, T.
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23:3452-3461, 2004
PubMed: 15297882 (PDB entries with the same primary citation)
DOI: 10.1038/sj.emboj.7600354
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267130.5%3.8%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report