1SL2

Ternary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template and an incoming nucleotide

Summary for 1SL2
Related1SKR 1SKS 1SKW 1SL0 1SL1 1T7P
Descriptor5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*TP*(2DA))-3', 5'-D(*CP*CP*CP*(TTD)P*AP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', DNA polymerase, ... (7 entities in total)
Functional Keywordsdna polymerase, fidelity, lesion bypass, thymine dimer, open, close, transferase-electron transport-dna complex, transferase/electron transport/dna
Biological sourceEnterobacteria phage T7
More
Total number of polymer chains4
Total formula weight105986.73
Authors
Li, Y.,Dutta, S.,Doublie, S.,Bdour, H.M.,Taylor, J.S.,Ellenberger, T. (deposition date: 2004-03-05, release date: 2004-07-06, Last modification date: 2011-07-13)
Primary citationBdour, H.M.,Doublie, S.,Dutta, S.,Ellenberger, T.,Li, Y.,Taylor, J.S.
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7.
Nat.Struct.Mol.Biol., 11:784-790, 2004
PubMed: 15235589
DOI: 110.1038/nsmb792
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-16