1SA4

human protein farnesyltransferase complexed with FPP and R115777

1SA4 の概要

• エントリーDOI: 10.2210/pdb1sa4/pdb
• 関連するPDBエントリー: 1D8D 1FT1 1JCQ 1JCR 1LD8 1O5M 1SA5
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: ftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, tumor regression, r115777, tipifarnib, zarnestra, fti, clinical candidate, inhibitor, protein prenylation, lipid modification, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94966.67

構造登録者

Reid, T.S.,Beese, L.S. (登録日: 2004-02-06, 公開日: 2004-06-08, 最終更新日: 2023-08-23)

• 主引用文献: Reid, T.S.,Beese, L.S.; Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity.; Biochemistry, 43:6877-6884, 2004; PubMed: 15170324; DOI: 10.1021/bi049723b

実験手法

X-RAY DIFFRACTION (2.1 Å)