1SA4
human protein farnesyltransferase complexed with FPP and R115777
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | polymer | 382 | 44864.8 | 1 | UniProt (P49354) Pfam (PF01239) In PDB | Homo sapiens (human) | CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha |
| 2 | B | Protein farnesyltransferase beta subunit | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) In PDB | Homo sapiens (human) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | C | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 4 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | B | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 6 | B | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE | non-polymer | 489.4 | 1 | Chemie (JAN) | |||
| 7 | water | water | 18.0 | 672 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P49354)
| PDB | External Database | Details |
|---|---|---|
| Glu 380 | - | insertion |
| Glu 381 | - | insertion |
| Phe 382 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93687.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 937.1 | |
| All* | Total formula weight | 94966.7 |
