1OGT

CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE VASOACTIVE INTESTINAL PEPTIDE TYPE 1 RECEPTOR (VIPR) PEPTIDE (RESIDUES 400-408)

1OGT の概要

• エントリーDOI: 10.2210/pdb1ogt/pdb
• 関連するPDBエントリー: 1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1CE6 1DE4 1E27 1E28 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1MI5 1OF2 1OGA 1QLF 1QQD 1TMC 2CLR 2HLA 3HLA
• 分子名称: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1, ... (6 entities in total)
• 機能のキーワード: immune system-complex, immune system, mhc (major histocompatibility complex), hla- b*2705
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45722.62

構造登録者

Hulsmeyer, M.,Fiorillo, M.T.,Bettosini, F.,Sorrentino, R.,Saenger, W.,Ziegler, A.,Uchanska-Ziegler, B. (登録日: 2003-05-13, 公開日: 2004-01-29, 最終更新日: 2024-11-13)

主引用文献

Hulsmeyer, M.,Fiorillo, M.T.,Bettosini, F.,Sorrentino, R.,Saenger, W.,Ziegler, A.,Uchanska-Ziegler, B.
Dual, HLA-B27 subtype-dependent conformation of a self-peptide.
J. Exp. Med., 199:271-281, 2004

PubMed Abstract: The products of the human leukocyte antigen subtypes HLA-B*2705 and HLA-B*2709 differ only in residue 116 (Asp vs. His) within the peptide binding groove but are differentially associated with the autoimmune disease ankylosing spondylitis (AS); HLA-B*2705 occurs in AS-patients, whereas HLA-B*2709 does not. The subtypes also generate differential T cell repertoires as exemplified by distinct T cell responses against the self-peptide pVIPR (RRKWRRWHL). The crystal structures described here show that pVIPR binds in an unprecedented dual conformation only to HLA-B*2705 molecules. In one binding mode, peptide pArg5 forms a salt bridge to Asp116, connected with drastically different interactions between peptide and heavy chain, contrasting with the second, conventional conformation, which is exclusively found in the case of B*2709. These subtype-dependent differences in pVIPR binding link the emergence of dissimilar T cell repertoires in individuals with HLA-B*2705 or HLA-B*2709 to the buried Asp116/His116 polymorphism and provide novel insights into peptide presentation by major histocompatibility antigens.

PubMed: 14734527
DOI: 10.1084/jem.20031690

実験手法

X-RAY DIFFRACTION (1.47 Å)