1N0T

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.

1N0T の概要

• エントリーDOI: 10.2210/pdb1n0t/pdb
• 関連するPDBエントリー: 1FTJ 1FTK 1FTL 1FTM 1FTO 1FWO 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7
• 分子名称: Glutamate receptor 2, (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: ionotropic glutamate receptor glur2, ligand-binding core, antagonist complex, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118619.03

構造登録者

Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.-L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S. (登録日: 2002-10-15, 公開日: 2003-03-04, 最終更新日: 2017-08-16)

• 主引用文献: Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S.; Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.; J.Med.Chem., 46:214-221, 2003; PubMed: 12519060; DOI: 10.1021/jm020989v

実験手法

X-RAY DIFFRACTION (2.1 Å)