1M79

Candida albicans Dihydrofolate Reductase Complexed with Dihydro-Nicotinamide-Adenine-Dinucleotide Phosphate (NADPH) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (GW1466)

1M79 の概要

• エントリーDOI: 10.2210/pdb1m79/pdb
• 関連するPDBエントリー: 1AI1 1AI2 1AI3 1AI4 1AI9 1AOE 1M78 1m7a
• 分子名称: dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-METHOXYPHENOXY)-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, antifungal target, reductase
• 由来する生物種: Candida albicans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46834.96

構造登録者

Whitlow, M.,Howard, A.J.,Kuyper, L.F. (登録日: 2002-07-19, 公開日: 2003-03-04, 最終更新日: 2024-02-14)

• 主引用文献: Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Kuyper, L.F.,Baccanari, D.P.,Fling, M.E.,Tansik, R.L.; X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex; J.Biol.Chem., 272:30289-30298, 1997; PubMed: 9374515; DOI: 10.1074/jbc.272.48.30289

実験手法

X-RAY DIFFRACTION (1.7 Å)