1LB1

Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA

Summary for 1LB1

Entry DOI	10.2210/pdb1lb1/pdb
Related	1FOE 1KI1 1KZ7 1KZG
Descriptor	Guanine nucleotide exchange factor DBS, Transforming protein RhoA (2 entities in total)
Functional Keywords	guanine nucleotide exchange factor, small g-protein, rhoa, dbs, dh domain, ph domain, signaling protein
Biological source	Mus musculus (house mouse) More
Cellular location	Cytoplasm: Q64096 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains	8
Total formula weight	251352.43
Authors	Snyder, J.T.,Worthylake, D.K.,Rossman, K.L.,Betts, L.,Pruitt, W.M.,Siderovski, D.P.,Der, C.J.,Sondek, J. (deposition date: 2002-04-01, release date: 2002-05-29, Last modification date: 2023-08-16)
Primary citation	Snyder, J.T.,Worthylake, D.K.,Rossman, K.L.,Betts, L.,Pruitt, W.M.,Siderovski, D.P.,Der, C.J.,Sondek, J. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9:468-475, 2002 Cited by PubMed: 12006984 DOI: 10.1038/nsb796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation