1LB1

Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Guanine nucleotide exchange factor DBS	polymer	353	41252.3	4	UniProt (Q64096) Pfam (PF00621) Pfam (PF22697) In PDB	Mus musculus (house mouse)	DBL'S BIG SISTER, DBS
2	B, D, F, H	Transforming protein RhoA	polymer	192	21585.8	4	UniProt (P61586) Pfam (PF00071) In PDB	Homo sapiens (human)	H12

Sequence modifications

A, C, E, G: 623 - 967 (UniProt: Q64096)

PDB	External Database	Details
Met 622	-	SEE REMARK 999
Ile 696	Asn 696	SEE REMARK 999
Phe 697	Ile 697	SEE REMARK 999
Leu 698	Pro 698	SEE REMARK 999
Arg 699	Ala 699	SEE REMARK 999
Glu 700	Gly 700	SEE REMARK 999
Leu 701	Val 701	SEE REMARK 999
Glu 968	-	expression tag
His 969	-	expression tag
His 970	-	expression tag
His 971	-	expression tag
His 972	-	expression tag
His 973	-	expression tag
His 974	-	expression tag

B, D, F, H: 1 - 190 (UniProt: P61586)

PDB	External Database	Details
Gly -1	-	SEE REMARK 999
Ala 0	-	SEE REMARK 999
Ser 190	Cys 190	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	251352.4
All*	Total formula weight	251352.4

*Water molecules are not included.