1KKQ
Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Summary for 1KKQ
Entry DOI | 10.2210/pdb1kkq/pdb |
Related | 1k74 1k7L |
Descriptor | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR, NUCLEAR RECEPTOR CO-REPRESSOR 2, N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE, ... (4 entities in total) |
Functional Keywords | nuclear corepressor nuclear hormone receptors antagonist, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 Q9Y618 |
Total number of polymer chains | 8 |
Total formula weight | 133211.69 |
Authors | Xu, H.E.,Stanley, T.B.,Montana, V.G.,Lambert, M.H.,Shearer, B.G.,Cobb, J.E.,McKee, D.D.,Galardi, C.M.,Nolte, R.T.,Parks, D.J. (deposition date: 2001-12-10, release date: 2002-02-20, Last modification date: 2023-08-16) |
Primary citation | Xu, H.E.,Stanley, T.B.,Montana, V.G.,Lambert, M.H.,Shearer, B.G.,Cobb, J.E.,McKee, D.D.,Galardi, C.M.,Plunket, K.D.,Nolte, R.T.,Parks, D.J.,Moore, J.T.,Kliewer, S.A.,Willson, T.M.,Stimmel, J.B. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature, 415:813-817, 2002 Cited by PubMed: 11845213PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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