1K7L
The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.
Summary for 1K7L
Entry DOI | 10.2210/pdb1k7l/pdb |
Related | 1fm6 1fm9 1k74 |
Descriptor | Peroxisome proliferator activated receptor alpha, steroid receptor coactivator, 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, ... (5 entities in total) |
Functional Keywords | the 2.5 angstrom resolution crystal structure of the human pparalpha ligand binding domain bound with gw409544 and a coactivator peptide, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 |
Total number of polymer chains | 8 |
Total formula weight | 142871.19 |
Authors | Xu, H.E.,Lambert, M.H.,Montana, V.G.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. (deposition date: 2001-10-19, release date: 2001-12-05, Last modification date: 2024-02-07) |
Primary citation | Xu, H.E.,Lambert, M.H.,Montana, V.G.,Plunket, K.D.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc.Natl.Acad.Sci.USA, 98:13919-13924, 2001 Cited by PubMed: 11698662DOI: 10.1073/pnas.241410198 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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