1K74

The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Summary for 1K74

• Entry DOI: 10.2210/pdb1k74/pdb
• Related: 1K7L 1fm6 1fm9
• Descriptor: Retinoic acid receptor RXR-alpha, Peroxisome proliferator activated receptor gamma, steroid receptor coactivator, ... (6 entities in total)
• Functional Keywords: the heterodimer of the nuclear receptor ligand binding domains of rxralpha and ppargamma bound respectively with 9-cis retinoic acid and gw409544 and coactivator peptides, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P19793 P37231
• Total number of polymer chains: 4
• Total formula weight: 65517.86

Authors

Xu, H.E.,Lambert, M.H.,Montana, V.G.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M. (deposition date: 2001-10-18, release date: 2001-12-05, Last modification date: 2024-02-07)

• Primary citation: Xu, H.E.,Lambert, M.H.,Montana, V.G.,Plunket, K.D.,Moore, L.B.,Collins, J.L.,Oplinger, J.A.,Kliewer, S.A.,Gampe Jr., R.T.,McKee, D.D.,Moore, J.T.,Willson, T.M.; Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.; Proc.Natl.Acad.Sci.USA, 98:13919-13924, 2001; PubMed: 11698662; DOI: 10.1073/pnas.241410198

Experimental method

X-RAY DIFFRACTION (2.3 Å)