1IA4
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)
1IA4 の概要
エントリーDOI | 10.2210/pdb1ia4/pdb |
関連するPDBエントリー | 1AI9 1AOE 1IA1 1IA2 1IA3 |
分子名称 | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total) |
機能のキーワード | oxidoreductase, antifungal target, reductase, dihydronicotinamide displaced |
由来する生物種 | Candida albicans |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 46977.25 |
構造登録者 | |
主引用文献 | Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F. X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor J.Med.Chem., 44:2928-2932, 2001 Cited by PubMed: 11520201DOI: 10.1021/jm0101444 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.85 Å) |
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