1IA3
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-[(4-TERT-BUTYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW995)
Summary for 1IA3
Entry DOI | 10.2210/pdb1ia3/pdb |
Related | 1AI9 1AOE 1IA1 1IA2 1IA4 |
Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[4-TERT-BUTYLPHENYLSULFANYL]-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, antifungal target, reductase, dihydronicotinamide displaced |
Biological source | Candida albicans |
Total number of polymer chains | 2 |
Total formula weight | 46919.26 |
Authors | Whitlow, M.,Howard, A.J.,Kuyper, L.F. (deposition date: 2001-03-22, release date: 2001-04-11, Last modification date: 2023-08-09) |
Primary citation | Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F. X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor J.Med.Chem., 44:2928-2932, 2001 Cited by PubMed: 11520201DOI: 10.1021/jm0101444 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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