1HWL

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ROSUVASTATIN (FORMALLY KNOWN AS ZD4522)

Summary for 1HWL
Related1HW8 1HW9 1HWI 1HWJ 1HWK 1dq8 1dq9 1dqa
DescriptorHMG-COA REDUCTASE, ADENOSINE-5'-DIPHOSPHATE, 7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains4
Total formula weight203301.91
Authors
Istvan, E.S.,Deisenhofer, J. (deposition date: 2001-01-09, release date: 2001-05-11, Last modification date: 2011-07-13)
Primary citationDeisenhofer, J.,Istvan, E.S.
Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292:1160-1164, 2001
PubMed: 11349148
DOI: 110.1126/science.1059344
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation
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PDB entries from 2021-06-16