1HW8
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)
Summary for 1HW8
Entry DOI | 10.2210/pdb1hw8/pdb |
Related | 1dq8 1dq9 1dqa 1HW9 1HWI 1HWJ 1HWK 1HWL |
Descriptor | HMG-COA REDUCTASE, (3R,5R)-3,5-dihydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]h eptanoic acid, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035 |
Total number of polymer chains | 4 |
Total formula weight | 202574.61 |
Authors | Istvan, E.S.,Deisenhofer, J. (deposition date: 2001-01-09, release date: 2001-05-11, Last modification date: 2023-08-09) |
Primary citation | Istvan, E.S.,Deisenhofer, J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science, 292:1160-1164, 2001 Cited by PubMed: 11349148DOI: 10.1126/science.1059344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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